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KMID : 0378019870300070033
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New Medical Journal
1987 Volume.30 No. 7 p.33 ~ p.40
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The Electrophysiological Studies of Sensory Receptors in the Cat´s Uterus
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Abstract
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The aim of this study is to determine whether the nociceptors which respond to potassium ion a bradykinin exist or not. Potassium ion 3.8 mg and bradykinin 26 pg were injected into the uterine ho tissue of cat via microCannule installed at -the branch of uterine. artery. And the recording was done to obtain the impulse discharges. from the uterine afferent nerve fibers at the distal stump of pelvic splanchnic nerve which had been believed to inervate the uterus.
The results are as follows:
1. Potassium ion increased the impulse discharges of 40 uterine afferents (40 of 43 uterine afferents shows the response of increased impulse discharges to potassium ion injected into uterine artery).
2. The uterine afterents which responded to injected potassium ion revealed no response to not only mechanical but also oxytocin stimulation of uterus.
3. Bradykinin increased the impulse discharges of 33 uterine afferents.
4. Both of mechanical and oxytocin stimulation of uterus had no effect on uterine afferents respondes to injected bradykinin.
To summarize the above results, the intra-arterially injected potassium ion and bradykinin could increase the impulse discharges of uterine afferent nerve fibers but the mechanical and oxytocin stimulation could not reveal such responses as those of the injected algesic substances. It suggests that the response of uterine afferents to algesic substances may represent the possible presence of nociceptors in the ute s and they may be pure nociceptors in view of showing unimodal responses.
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